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Well there was a McGuyver episode where a thief made off with a woman's son's baseball card collection(stuff from the 40's and 50's) and he went to card shops trying to find the collection.
Also, the movie The Mask with Cher, the kid collected cards and pinned them on a tac board.
One of the Simpson's episodes featured Milhouse, Bart, and one of the other kids that pooled their money together to buy a comic book for $100 that subsequently got destroyed. Anyways...Milhouse wanted to use his money to buy a 1973 Carl Yastrzemski, the one with the sideburns
Needful Things with the Koufax Rookie
FIFY
There was a movie about a guy who was locked in a bomb shelter his whole life and when he finally gets out he sells off his old baseball cards...
It starred the guy from the Mummy movies.
In the movie it was Mantle, in the book it was KoufaxDude...it's been a while.And...I just snagged needful things on dvd. I thought it was a Mantle. Damn... As far as the simpsons goes, I remember that back when I was in high school so it's been at least 11 years if not more. I know at least they were after a Radioactive Man #1 for the $100 which then got blown out of their tree house after they fought over who got to take it home. Then it fell onto the ground and was rained on and then lightning hit it.